Protein Modification Reagents

eMolecules​ 2107273-26-5 | N-(m-PEG9)-N'-(PEG5-acid)-Cy5 | Broadpharm1093.790 | C57H89ClN2O16 | 97.000 | [Cl-].COCCOCCOCCOCCOCCOCCOCCOCCOCCN1\C(=C\C=C\C=C\C2=[N+](CCOCCOCCOCCOCCOCCC(O)=O)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 1mg | 298819341

N-(m-PEG9)-N'-(PEG5-acid)-Cy5 | Broadpharm | 2107273-26-51093.790 | C57H89ClN2O16 | 97.000 | [Cl-].COCCOCCOCCOCCOCCOCCOCCOCCOCCN1\C(=C\C=C\C=C\C2=[N+](CCOCCOCCOCCOCCOCCC(O)=O)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 1mg | 298819341

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eMolecules​ 14-(Azide-PEG4-ethylcarbamoyl)tridecanoic-t-butyl ester | Broadpharm |558.761 | C28H54N4O7 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784455327

14-(Azide-PEG4-ethylcarbamoyl)tridecanoic-t-butyl ester | Broadpharm |558.761 | C28H54N4O7 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784455327

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eMolecules​ Cy5-PEG4-acid | BroadpharmMFCD28142461 | 766.420 | C43H60ClN3O7 | 96.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCC(O)=O)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 10mg | 263744692

Cy5-PEG4-acid | BroadpharmMFCD28142461 | 766.420 | C43H60ClN3O7 | 96.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCC(O)=O)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 10mg | 263744692

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eMolecules​ Aminooxy-PEG1-amine | 1510385-08-6 | | 250mg

Broadpharm | Aminooxy-PEG1-amine | 250mg | 550804660 | BP-24470 | 98.000 | 1510385-08-6 | | 120.152 | C4H12N2O2

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eMolecules​ 557756-85-1 | Fmoc-NH-PEG4-CH2CH2COOH | Ambeed | MFCD06656472 | 487.549 | C26H33NO8 | 98.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100mg | 490490352

Fmoc-NH-PEG4-CH2CH2COOH | Ambeed | 557756-85-1 | MFCD06656472 | 487.549 | C26H33NO8 | 98.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 100mg | 490490352

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Medchemexpress LLC Mal-amido-PEG4-acid | 1263045-16-4 | 99.8% | 250 MG

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Mal-amido-PEG4-acid, also known as 4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-, is a high-purity PEG-based PROTAC linker. It is primarily utilized in the synthesis of PROTACs, enabling targeted protein degradation. This compound is characterized by its specific molecular formula C18H28N2O9 and molecular weight of 416.42. It appears as an off-white to yellow solid.

• PEG-based PROTAC linker
• Used in the synthesis of PROTACs
• Appears as an off-white to yellow solid
• Purity of 99.76% by HPLC

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Medchemexpress LLC M-PEG5-CH2CH2COOH | 1347750-72-4 | MFCD20926383 | >95.0% | 324.37 | C14H28O8 | 5 G

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m-PEG5-CH2CH2COOH is a methyl-capped polyethylene glycol (PEG5) linker terminating in a carboxylic acid. It is used as a short PEG spacer for conjugation in PROTAC and ADC synthesis, providing solubility and a reactive terminal carboxyl for coupling reactions.

• Methyl-capped PEG5 spacer with terminal carboxylic acid.
• Designed for use in PROTAC and ADC linker synthesis.
• Typical purity ≥95.0%.
• Molecular weight 324.37 and formula C14H28O8.
• Available in small-scale packages including 5 g.
• Store pure material at -20°C for long-term stability.

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Medchemexpress LLC Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) | 1799506-30-1 | 98.0% | 370.87 | 50 MG

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Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs). This product is for research use only. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting an E3 ubiquitin ligase ligand and a target protein ligand via a linker.

• Appearance: oil
• Color: colorless to light yellow
• Chemical formula: C16H31ClO7
• Shipping: room temperature in continental US
• Storage in pure form: -20°C for 3 years, 4°C for 2 years
• Storage in solvent: -80°C for 6 months, -20°C for 1 month
• Solubility in ethanol: 100 mg/mL (needs ultrasonic)
• Solubility in DMSO: 100 mg/mL (needs ultrasonic, use newly opened DMSO)

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Medchemexpress LLC Cpth2-alkyne | 1613116-16-7 | 99.0% | 1 MG

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Alkyne-tagged analog of a NAT10 inhibitor used as a cell-active chemical probe to study nuclear architecture and laminopathy. The compound localizes to nucleoli, nuclear periphery, and cytoplasm, and is used for cell-based localization and target engagement studies.

• Alkyne tag for bioorthogonal chemistry applications.
• Cell active and accumulates in nucleoli.
• Inhibits N-acetyltransferase 10 (NAT10).
• High reported purity suitable for biochemical assays.
• Available in a 1 mg research quantity.

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Medchemexpress LLC DSPE-PEG-Folate | 1236288-25-7 | 95.7% | 3400.00 | C65H114N11O16P | 5 MG

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DSPE-PEG-Folate is a pegylated phospholipid bearing a terminal folate group that enables folate-receptor mediated targeting. It integrates into lipid bilayers or forms micelles for use in liposome and nanoparticle drug-delivery research and targeting studies.

• Enables folate-mediated targeting to folate receptor-expressing cells.
• Integrates into lipid bilayers and forms micelles for nanoparticle and liposome formulation.
• Terminal folate provides a handle for receptor-specific delivery.
• High purity suitable for research applications (reported ~95.7%).
• Available in small research pack sizes for formulation screening.

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eMolecules​ 1807537-41-2 | AZD-PEG2 -PFP | Broadpharm | MFCD27635165 | 572.485 | C26H25F5N2O7 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)c(F)c1F | 100mg | 229582342

AZD-PEG2 -PFP | Broadpharm | 1807537-41-2 | MFCD27635165 | 572.485 | C26H25F5N2O7 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)c(F)c1F | 100mg | 229582342

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Medchemexpress LLC DBCO-PEG24-acid | 2765066-36-0 | C70H116N2O28 | 5 MG

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DBCO-PEG24-acid is a click chemistry reagent and an analog of DBCO-Acid featuring a PEG linker and a DBCO group. The DBCO group is utilized in copper-free Click Chemistry reactions due to its strain-promoted high energy. The hydrophilic PEG chain enhances water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g., EDC or HATU) to form a stable amide bond. This product is reagent grade and intended for research use only.

• Click chemistry reagent
• Analog of DBCO-Acid with PEG linker and DBCO group
• DBCO group for copper-free Click Chemistry reactions
• Strain-promoted high energy DBCO group
• Hydrophilic PEG chain enhances water solubility
• Terminal carboxylic acid reacts with primary amine groups
• Forms stable amide bond with activators (e.g., EDC or HATU)
• Reagent grade
• Intended for research use only

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Medchemexpress LLC Dbco-peg4-vc-pab-mmae | 2129164-91-4 | 99.2% | 1658.03 | C88H128N12O19 | 10 MG

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DBCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate intended for use in antibody-drug conjugate (ADC) synthesis. The molecule combines a DBCO click-functional group, a PEG4 spacer, a valine-citrulline (Val-Cit) cleavable linker with a para-aminobenzyl (PAB) spacer, and the cytotoxic payload monomethyl auristatin E (MMAE). It is supplied as a powder for research use only.

• Enables strain-promoted alkyne-azide cycloaddition (SPAAC) to azide-containing biomolecules.
• Hydrophilic PEG4 spacer improves solubility and reduces aggregation.
• Val-Cit-PAB linker is cleavable under lysosomal conditions for payload release.
• High purity suitable for conjugation workflows.
• Soluble in DMSO at 150 mg/mL; may require ultrasonic treatment.
• Store as powder at -20°C for optimal stability.

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eMolecules​ TAMRA-PEG4-Tetrazine | BroadpharmMFCD29052199 | 846.942 | C45H50N8O9 | 95.000 | CN(C)c1ccc2c(-c3ccc(cc3C([O-])=O)C(=O)NCCOCCOCCOCCOCCC(=O)NCc3ccc(cc3)-c3nncnn3)c3ccc(cc3oc2c1)=[N+](C)C | 1mg | 296213310

TAMRA-PEG4-Tetrazine | BroadpharmMFCD29052199 | 846.942 | C45H50N8O9 | 95.000 | CN(C)c1ccc2c(-c3ccc(cc3C([O-])=O)C(=O)NCCOCCOCCOCCOCCC(=O)NCc3ccc(cc3)-c3nncnn3)c3ccc(cc3oc2c1)=[N+](C)C | 1mg | 296213310

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Cayman Chemical TrImethoprIm-PEG-amIntrIfl 5mg

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A conjugated form of trimethoprim linked with polyethylene glycol (PEG) amine

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